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Rec. INN (наименование, зарегистрированное ВОЗ)

2642374-04-5

immunoglobulin G4-kappa, anti-[Homo sapiens EDNRA (endothelin receptor type A, ETA, ET-A, ETA-R, ET-AR)], humanized monoclonal antibody;
gamma4 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-5*09 (88.9%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [10.7.12] (26-35.53-59.98-109)) (1-120) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v4 CH2 A1.3, A1.2 (CH1 (121-218), hinge 1-12 S10>P (228) (219-230), CH2 F1.3>A (234), L1.2>A (235), L92 (309) (231-340), CH3 (341-445), CHS K2>del (446)) (121-446)], (134-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV6-21*02 (90.5%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO) Cell line, glycoform alfa

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