Патритумаб дерукстекан

Rec. INN (наименование, зарегистрированное ВОЗ)

2227102-46-5

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)], Homo sapiens monoclonal antibody, conjugated to deruxtecan, comprising a linker and a camptothecin derivative;
gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV4-34*01 (99.0%) -(IGHD) -IGHJ2*01 (100%)) [8.7.11] (1-117) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 (CH1 R120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 E12 (356), M14 (358) (341-445), CHS (446-447)) (123-452)], (220-220')-disulfide with kappa light chain Homo sapiens (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (95.0%) -IGKJ1*01 (100%)) [12.3.9] (1'-113') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (159), V101 (197) (114'-220')];
dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO) cell line, glycoform alfa; conjugated, on an average of 8 cysteinyl, to deruxtecan, comprising a linker and a camptothecin derivative

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