Павурутамаб

Pavurutamab

МНН

Rec. INN (зарегистрированное ВОЗ)

CAS

2250292-39-6

Химическое название

immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens TNFRSF17 (TNF receptor superfamily member 17, tumor necrosis factor receptor superfamily, member 17, B cell maturation antigen, BCMA, BCM, TNFRSF13A, CD269)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific;
IG single chain scFv-scFv-scFc, anti-TNFRS17 and anti-CD3E (1-986) [scFv-VH-V-kappa anti-TNFRSF17 (1-243) [VH (Homo sapiens IGHV1-46*01 G49>C (44) (84.7%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -15-mer tris(tetraglycyl-seryl) linker (122-136) -V-KAPPA (Homo sapiens IGKV1-33*01 (91.6%) -IGKJ1*01 Q120>C (236) (91.7%)) CDR-IMGT [6.3.9] (163-168.186-188.225-233) (137-243)] -6 mer seryl-tetraglycyl-seryl linker (244-249) -scFv-VH-V-lambda anti-CD3E (250-498) [VH (Mus musculus IGHV10-1*02 (91.9%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-73*01 (87%) -(IGHD) -IGHJ5*01 (100%)) CDR-IMGT [8.10.16] (275-282.300-309.348-363) (250-374) -15-mer tris(tetraglycyl-seryl) linker (375-389) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%)) CDR-IMGT [9.3.9] (415-423.441-443.480-488) (390-498)] -4-mer tetraglycyl linker (499-502) -scFc (h-CH2-CH3)-(h-CH2-CH3) (503-986) [Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (hinge 6-15 (503-512), CH2 R83>C (574), N84.4>G (579), V85>C (584) (513-622), CH3 E12 (638), M14 (640) (623-727), CHS (728-729)) (503-729) -30-mer hexakis(tetraglycyl-seryl) linker (730-759) -Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (hinge 6-15 (760-769), CH2 R83>C (831), N84.4>G (836), V85>C (841) (770-879), CH3 E12 (895), M14 (897) (880-984), CHS (985-986)) (760-986)], produced in Chinese hamster ovary (CHO) cells, non-glycosylated

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