Пебоктокоген камапарвовек
Peboctocogene camaparvovecМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Химическое название
A non-replicating adeno-associated virus serotype hu37 (AAVhu37) vector encoding B-domain deleted human blood-coagulation factor VIII.
A recombinant, non-replicating, adeno-associated virus serotype hu37 (AAVhu37) vector, encoding a codonoptimised B-domain deleted SQ variant of human bloodcoagulation factor VIII (hFVIII-SQ), under the control of a hybrid liver promoter (Mus musculus transthyretin enhancerhuman transthyretin promoter) and a synthetic polyA signal sequence, flanked by AAV2 inverted terminal repeats; the A2 and A3 domains of hFVIII are linked by a DNA sequence encoding a 14-amino acid peptide (SQ) from the B domain.
A recombinant, non-replicating, adeno-associated virus serotype hu37 (AAVhu37) vector, encoding a codonoptimised B-domain deleted SQ variant of human bloodcoagulation factor VIII (hFVIII-SQ), under the control of a hybrid liver promoter (Mus musculus transthyretin enhancerhuman transthyretin promoter) and a synthetic polyA signal sequence, flanked by AAV2 inverted terminal repeats; the A2 and A3 domains of hFVIII are linked by a DNA sequence encoding a 14-amino acid peptide (SQ) from the B domain.
Структура
Иностранные названия
- Peboctocogenum camaparvovecum (латинское)
- Peboctocogene camaparvovec (английское)
- Peboctocogen camaparvovec (немецкое)
- Péboctocogène camaparvovec (французское)
- Peboctocogén camaparvovec (испанское)
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