Пегипанермин

Rec. INN (наименование, зарегистрированное ВОЗ)

2489785-77-3

human tumor necrosis factor (TNF, TNF-alfa, tumor necrosis factor ligand superfamily member 2) soluble fragment (77-233, 1-157 in the current sequence) variant (V⁷⁷>M¹, R¹⁰⁷>C³¹, C¹⁴⁵>V⁶⁹, Y¹⁶³>H⁸⁷, C¹⁷⁷>A¹⁰¹, A²²¹>R¹⁴⁵), pegylated at Cys31 with monomethoxy-polyethylene glycol (mPEG, MW ~10 kDa, n ~225), non-glycosylated, produced in Escherichia coli; human tumor necrosis factor (TNF, TNF-α, TNFA, tumor necrosis factor ligand superfamily member 2, TNFSF2, cachectin) (77-233)-peptide (TNF soluble form, sTNF, 1-157) [V¹>M, R³¹>C, C⁶⁹>V, Y⁸⁷>H, C¹⁰¹>A, A¹⁴⁵>R]-mutant, non- glycosylated, produced in Escherichia coli, conjugated at Cys31 with an S-{1-[3-({3-[α-methylpoly(oxyethylene)-ω- oxy]propyl}amino)-3-oxopropyl]-2,5-dioxopyrrolidin-3-yl} group

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