Пегризепрумент

Prop. INN (наименование, предложенное ВОЗ)

2829316-24-5

immunoglobulin Fab VH-G1CH1h_L-kappa, anti-[Homo sapiens CD28 (T cell specific surface glycoprotein CD28, TP44)], conjugated to a bi-branched polyethylene glycol (PEG) chain; VH-CH1 chain (1-232) [VH Musmus/Homsap (Mus musculus IGHV1-62-2*01 (84.0%) -(IGHD) -IGHJ3*01 (100%)/Homo sapiens IGHV1-2*02 (63.3%) -(IGHD) -IGHJ4*01 (91.7%) S128>A (121), CDR-IMGT [8.8.14] (26-34.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01 CH1-h, G1m17 CH1 K120 (CH1 K120 (218) (122-219), hinge 1-11 (220-230) -2-mer bisalanyl (231-232)) (122-232)], (224- 214')-disulfide with L-kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV12-46*01 (83.2%) - IGKJ1*01 (100%)/Homo sapiens IGKV1-NL1*01 (74.4%) -IGKJ2*02 (91.7%) Q120>G (100'), CDR-IMGT [6.3.9] (27'-32'.51'-53'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')], produced in Chinese hamster ovary (CHO) cells, expressing the enzyme glutamine synthetase (GS), non- glycosylated; substituted at the sulfur atoms of L-cysteinyl residue 230 with group (3Ξ)-1-{3-[(3-{(2Ξ)-2,3-bis[ω- methoxypoly(oxyethylene)-α-yl]propoxy}propyl)amino]-3- oxopropyl}-2,5-dioxopyrrolidin-3-yl

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