Пелунтамиг

Prop. INN (наименование, предложенное ВОЗ)

2928515-21-1

immunoglobulin H-gamma1_L-kappa, anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3) and anti-[Homo sapiens DLL3 (delta-like ligand 3, delta like canonical Notch ligand 3)], bispecific;  
H-gamma1 heavy chain anti-CD47 (1-444) [VH (Homo sapiens IGHV1-46*01 (88.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.7] (26-33.51-58.97-103)) (1-114) -Homo sapiens IGHG1*01 G1m17,1 CH1 K120, CH3 D12, L14, G1v74 CH3 C10, G1v32 CH3 W22 (knob) (CH1 K120 (211) (115-212), hinge 1-15 (213-227), CH2 (228-337), CH3 S10>C (351), D12 (353), L14 (355), T22>W (363) (338-442), CHS (443-444)) (115-444)], (217-214')- disulfide with common L-kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV3-20*01 (84.4%) -IGKJ1*01 (91.7%), CDR-IMGT [6.3.9] (27’-32’.50’-52’.89’-97’)) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')];
H-gamma1 heavy chain anti-DLL3 (1’’-448’’) [VH Musmus/Homsap (Mus musculus IGHV1-14*02 (71.4%) -(IGHD) -IGHJ2*01 (69.2%) Q120>R (110''), T122>A (112’’), T123>P (113’’), L124>V (114'')/Homo sapiens IGHV1-3*01 (65.3%) -(IGHD) -IGHJ4*01 (76.9%), CDR-IMGT [8.8.11] (26’’-33''.51''-58''.97''-107'')) (1’’-118’’) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v75 CH3 C5, G1v33 CH3 S22, A24, V86 (hole) (CH1 K120 (215’’) (119’’-216’’), hinge 1-15 (217’’-231’’), CH2 (232''-341''), CH3 Y5>C (350''), D12 (357''), L14 (359''), T22>S (367’’), L24>A (369’’), Y86>V (408’’) (342’’-446’’), CHS (447’’-448'')) (119''-448’’)], (221''-214''')-disulfide with common L-kappa light chain (1'''-214''') [V-KAPPA (Homo sapiens IGKV3-20*01 (84.4%) -IGKJ1*01 (91.7%), CDR-IMGT [6.3.9] (27'''-32'''.50'''-52'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'''), V101 (191''')) (108'-214''')]; dimer (223-227'':226-230'':351-350'')-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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