Пемлимоген меролисбак

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB16286

Recombinant live-attenuated double-deleted (LADD) strain of Listeria monocytogenes (Lm ∆actA/∆inlB) expressing a fusion protein comprising the N-terminal 100 amino acids of the Lm ActA protein (ActAN100), 5 tandem copies of a 21 amino acid fragment of human epidermal growth factor receptor variant III (EGFRvIII) and amino acids 35-622 of human mesothelin (MSLN), under the control the Lm actA (actin-assembly inducing protein precursor) promoter, and contained within an expression cassette of 3874 bp inserted at the Lm tRNA^Arg locus.

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