Пертузумаб зувотолимод

Rec. INN (наименование, зарегистрированное ВОЗ)

2500674-05-3

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, conjugated via a cleavable linker to an analogue of motolimod (an agonist for the toll-like receptor 8, TLR8);
gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-66*01 (78.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS K2>del (448)) (120-448)], (222-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (84.2%) -IGKJ2*01 (91.7%) L124>V (104), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa, substituted at S of an average of 4 cysteinyl residues of reduced inter-chain disulfide bridges with (11S,14S,22³RS)-1²-amino-11-[3-(carbamoylamino)propyl]-1⁴-(dipropylcarbamoyl)-2,5,10,13,16,22²,22⁵-heptaoxo-14-(propan-2-yl)-4⁷,4⁸-dihydro-1³H,4⁵H-6-oxa-3,9,12,15-tetraaza-1(8)-[1]benzazepina-4(3,6)-[1,6]naphthyridina-22(1)-pyrrolidina-8(1,4)-benzenadocosaphan-22³-yl (zuvotolimod) groups

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