Пламотамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2138442-31-4

immunoglobulin half-G1-kappa/scFv-h-CH2-CH3, anti- [Homo sapiens MS4A1 (membrane-spanning 4-domains subfamily A member 1, CD20) and Homo sapiens CD3 epsilon (CD3E, Leu-4)], monoclonal antibody, bispecific;
gamma1 heavy chain anti-MS4A1 (1-450) [VH (Homo sapiens IGHV1-3*01 (88.8%) -(IGHD) -IGHJ2*01 (81.2%)) [8.8.14] (1-121) -Homo sapiens IGHG1*03v (CH1 N114>D (212), R120>K (218) (122-219), hinge 1-15 (220-234), CH2 E1.4>P (237), L1.2>V (238), G1.1>A (239), S29>K (270), Q84.2>E (298) (235-343), CH3 E12 (359), M14 (361), L24>D (371), K26>S (373), N44>D (387), Q97>E (421), N100>D (424) (344-448), CHS (449-450)) (122-450)],(224-213')-disulfide with kappa light chain anti-MS4A1 (1'-213') [V-KAPPA (Homo sapiens IGKV1-16*01 (80.9%) -IGKJ4*01 (100%)) [5.3.9] (1'-106') -Homo sapiens IGKC*01 (100%) A45.1 (152), V101 (190) (107'-213')]; heavy chain scFv-h-CH2-CH3, anti-CD3E (1-485) [VH (Homo sapiens IGHV3-73*01 (87.0%) -(IGHD) -IGHJ6*01 (90.9%)) [8.10.16] (1-125) - 20-mer linker (126-145) -V-LAMBDA (Mus musculus IGLV1*01 (80.6%) -IGLJ1*01 (100%)/Homo sapiens IGLV7-46*01 (76.8%) - IGHJ3*02 (100%)) [9.3.9] (146-254) -IGHG1*03 (hinge 1-15 C5>S (259) (255-269) -CH2 E1.4>P (272), L1.2>V (273), G1.1>A (274), S29>K (305) (270-378),CH3 E12 (394), E13>Q (395), M14 (396), S20>K (402)(379-483), CHS (484-485)) (1-485)]; (230-265'':233-268'')- bisdisulfide

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