Подентамиг

Prop. INN (наименование, предложенное ВОЗ)

2851863-52-8

immunoglobulin single chain VH-VH'-scFvhl, anti-[Homo sapiens TNFRSF17 (TNF receptor superfamily member 17, BCMA, TNFRSF13A, CD269)], anti-[Homo sapiens ALB (albumin, human serum albumin, HSA)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], trispecific;
IG single chain VH-VH'-scFvhl (1-507) [VH anti-TNFRSF17 Vicpac /Homsap (Vicugna pacos IGHV3S53*01 (83.3%) -(IGHD) -IGHJ4*01 (100%)/Homo sapiens IGHV3-23*04 (73.5%) -(IGHD) -IGHJ4*01 (91.7%) L123>Q (114), (CDR-IMGT [8.6.14] (27-33.51-56.95-108)) (1-119) -9-mer-tetraglycyl-seryl-triglycyl-seryl linker (120-128) -VH anti-ALB (Homo sapiens IGHV3-23*04 (88.5%) -(IGHD) -IGHJ1*01 (81.8%) W118>S (333), G119>S (334), CDR-IMGT [8.8.8] (154-161.179-186.225-232)) (129-243) -9-mer-tetraglycyl-seryl-triglycyl-seryl linker (244-252) - scFvhl anti-CD3E (253-507) [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (89.9%) -(IGHD) -IGHJ3*01 (100%)/Homo sapiens IGHV3-73*01 (85.0%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.10.16] (278-285.303-312.351-366)) (253-377) -15-mer-tris(tetraglycyl-seryl) linker (378-392) -V-LAMBDA (Homo sapiens IGLV7-43*01 (86.2%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (418-426.444-446.483-491)) (393-501)] -hexahistidine tag (502-507)], produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, lacking the enzyme dihydrofolate reductase (DHFR), non-glycosylated

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