Посдинемаб
PosdinemabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2517973-04-3
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens MAPT (microtubule associated protein tau, tau), phosphorylated], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-30*01 (93.9%) -(IGHD) -IGHJ5*01 (80.0%) G121>V (111), CDR-IMGT [8.7.12] (26-33.51-57.96-107)) (1-118) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 E12 (357), M14 (359) (342-446), CHS (447-448)) (119-448)], (221-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-16*01 (85.3%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-30*01 (93.9%) -(IGHD) -IGHJ5*01 (80.0%) G121>V (111), CDR-IMGT [8.7.12] (26-33.51-57.96-107)) (1-118) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 E12 (357), M14 (359) (342-446), CHS (447-448)) (119-448)], (221-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-16*01 (85.3%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Структура
Иностранные названия
- Posdinemabum (латинское)
- Posdinemab (английское)
- Posdinemab (немецкое)
- Posdinémab (французское)
- Posdinemab (испанское)
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