Поснафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2797073-53-9

humanized immunoglobulin G1-kappa antigen-binding fragment (Fab), anti-[human transferrin receptor 1 (hTfR, p90, CD71)] fused at the C-terminus of the heavy chain via a peptide linker to human N-sulphoglucosamine sulphohydrolase (SGSH, sulfoglucosamine sulfamidase, sulphamidase, EC:3.10.1.1);
gamma 1 heavy Fab chain (1-226) [VH (Homo sapiens IGHV5- 51*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.9] (31-35.50-66.99-107)) (1-118) -Homo sapiens IGHG1*01 (CH1 (119-226)] fused via peptide linker ²²⁷GGGGSGGGGSGGGGS²⁴¹ to N- sulphoglucosamine sulphohydrolase (1-482, 242-723 in the current sequence), residue 291 posttranslationally modified to formylglycine (fGly), (221-219')-disulfide with kappa light chain (1'- 219') [V-KAPPA (Homo sapiens IGKV2D-29*02 -IGKJ1*01, CDR- Kabat [16.7.9] (24'-39'.55'-61'.94'-102')) (1'-112') -Homo sapiens IGKC*01 (113'-219')]; non-covalent dimer, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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