Посолейцел
PosoleucelМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
PubChem
440234864
Химическое название
Allogeneic human leukocyte antigen (HLA)-matched virus-specific T cells reactive to cytomegalovirus (CMV), EBV, BK virus, adenovirus and human herpesvirus-6 (HHV-6). The cells are derived from peripheral blood mononuclear cells (PBMCs) from donors seropositive for all five of these viruses.
The cells are expanded and co-cultured with 15-mer peptides overlapping by 11 amino acids spanning antigenic proteins from polyomaviruses BK and JC (VP1 and large T), from adenovirus (hexon and penton), from cytomegalovirus (IE1 and pp65), from Epstein-Barr virus (LMP2, EBNA1, BZLF1), and from human herpesvirus-6 (U90, U11 and U14). The cells have specific anti-virus reactivity for each virus above a pre-specified potency threshold, and predominantly express CD3 (generally >95%) with a mixture of CD4+ (average 60%) and CD8+ (average 34%) subsets, including both central (CD45RA-/62L+/CCR7+) and effector (CD45RA-/62L-/CCR7-) memory markers.
The cells are expanded and co-cultured with 15-mer peptides overlapping by 11 amino acids spanning antigenic proteins from polyomaviruses BK and JC (VP1 and large T), from adenovirus (hexon and penton), from cytomegalovirus (IE1 and pp65), from Epstein-Barr virus (LMP2, EBNA1, BZLF1), and from human herpesvirus-6 (U90, U11 and U14). The cells have specific anti-virus reactivity for each virus above a pre-specified potency threshold, and predominantly express CD3 (generally >95%) with a mixture of CD4+ (average 60%) and CD8+ (average 34%) subsets, including both central (CD45RA-/62L+/CCR7+) and effector (CD45RA-/62L-/CCR7-) memory markers.
Иностранные названия
- Posoleucelum (латинское)
- Posoleucel (английское)
- Posoleucel (немецкое)
- Posoleucel (французское)
- Posoleucel (испанское)
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