Поветацицепт

Rec. INN (наименование, зарегистрированное ВОЗ)

2490217-42-8

human TACI (transmembrane activator and CAML interactor, tumor necrosis factor receptor superfamily member 13B, CD267) receptor domain, fragment 68-110 (1-43 in the current sequence) variant (K⁷⁷>E¹⁰, F⁷⁸>Y¹¹, Y¹⁰²>D³⁵), fused via the peptide linker 44GSGGGGS50 to a human immunoglobulin G1 C-terminal Fc fragment (51-281) variant (C⁵⁵>S, L⁶⁹>A, L⁷⁰>E, G⁷²>A, C-terminal K²⁸² deleted), disulfide bridged dimer, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1 GS-, glycoform alfa; human TACI (transmembrane activator and CAML interactor, tumor necrosis factor receptor superfamily member 13B, TNFRSF13B, CD267) receptor domain 68-110 fragment (K⁷⁷>E¹⁰, F⁷⁸>Y¹¹, Y¹⁰²>D³⁵)-mutant (1-43), fused via a GSG4S peptide linker (44-50) with 232 C-terminal residues of a mutated human immunoglobulin G1 gamma1 heavy chain (51- 281) [Homo sapiens IGHG1*01, hinge C⁵⁵>S (51-65), CH2 L⁶⁹>A, L⁷⁰>E, G⁷²>A (66-175), CH3 (176-280), CHS K²⁸²>del (281)], (61-61':64-64')-bisdisulfide dimer, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1 GS-, glycoform alfa

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