Прадусинстобарт
PradusinstobartМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2642171-66-0
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)], humanized monoclonal antibody;
gamma4 heavy chain humanized (1-448) [VH humanized (Homo sapiens IGHV2-5*08 (89.0%) -(IGHD) -IGHJ5*01 (86.7%), CDR-IMGT [10.7.13] (26-35.53-59.98-110)) (1-121) -Homo sapiens IGHG4*01, IGHG4v5 h P10, nG4m(a) CH2 L92 (CH1 (122-219), hinge 1-12 S10>P (229) (220-231), CH2 L92 (310) (232-341), CH3 (342-446), CHS (447-448)) (122-448)], (135-213')-disulfide with kappa light chain Homo sapiens (1'-213') [V-KAPPA Homo sapiens IGKV1-16*01 (86.2%) -IGKJ4*01 (100%), CDR-IMGT [6.3.8] (27-32.50-52.89-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from CHO-K1 cell line, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
gamma4 heavy chain humanized (1-448) [VH humanized (Homo sapiens IGHV2-5*08 (89.0%) -(IGHD) -IGHJ5*01 (86.7%), CDR-IMGT [10.7.13] (26-35.53-59.98-110)) (1-121) -Homo sapiens IGHG4*01, IGHG4v5 h P10, nG4m(a) CH2 L92 (CH1 (122-219), hinge 1-12 S10>P (229) (220-231), CH2 L92 (310) (232-341), CH3 (342-446), CHS (447-448)) (122-448)], (135-213')-disulfide with kappa light chain Homo sapiens (1'-213') [V-KAPPA Homo sapiens IGKV1-16*01 (86.2%) -IGKJ4*01 (100%), CDR-IMGT [6.3.8] (27-32.50-52.89-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from CHO-K1 cell line, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
Структура
Иностранные названия
- Pradusinstobartum (латинское)
- Pradusinstobart (английское)
- Pradusinstobart (немецкое)
- Pradusinstobart (французское)
- Pradusinstobart (испанское)
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