Прецемтабарт тоцентекан

Prop. INN (наименование, предложенное ВОЗ)

2873366-83-5

immunoglobulin G1-kappa, anti-[Homo sapiens CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5, CEA, CD66e)], Homo sapiens monoclonal antibody, conjugated on an average of 8 cysteinyl residues to tocentecan, comprising a linker and a camptothecin derivative (exatecan);
H-gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV4-31*02 (90.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [10.7.11] (26-35.53-59.98-108)) (1-119) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v50 CH2 delE1.4, P1.3, V1.2, A1.1, G1v60 CH2 S115, S116 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 E1.4>del, L1.3>P (235), L1.2>V (236), G1.1>A (237), A115>S (331), P116>S (332) (233-341), CH3 E12 (357), M14 (359) (342-446), CHS K2>del (447)) (120-447)], (222-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-15*01 (94.7%) -IGKJ3*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa; substituted at the sulfur atoms of an average of 8 l-cysteinyl residues among 222, 228, 231, 214', 222'', 228'', 231'' and 214''' with radical group 1-{3-[(2-{5-[({[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]carbamoyl}oxy)methyl]-2-(β-d-glucopyranuronosyloxy)anilino}-2-oxoethyl)amino]-3-oxopropyl}-2,5-dioxopyrrolidin-3-yl (tocentecan)

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