Притебеген зепаденовек

Prop. INN (наименование, предложенное ВОЗ)

replication-deficient chimpanzee adenovirus vector (ChAdOx1- ΔE1 ΔE3 E4-modified), encoding a codon-optimized fusion protein containing multiple hepatitis B virus (HBV) antigens, comprising the HBV pre-core antigen, core antigen, a non- functional polymerase, a C-terminal fragment of the HBV Pre-S1 protein and the Pre-S2 protein, all preceded by a shark Invariant (Sli) chain sequence and separated by a self-cleaving foot-and- mouth virus F2A peptide sequence from the leader sequence of human tissue plasminogen activator, followed by an N-terminal fragment of the HBV Pre-S1 protein and the HBV surface antigen (HbSAg), under control of a human cytomegalovirus (CMV) promoter and a bovine growth hormone polyadenylation signal., The transgene is inserted in the deleted E1 region of the viral vector genome

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