Пукотенлимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2403647-03-8

immunoglobulin G4-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)], monoclonal antibody;
gamma4 heavy chain (1-445) [ (Mus musculus IGHV5-9-2*01 (87.8%) -(IGHD) -IGHJ3*01 (93.3%)/Homo sapiens IGHV3-23*04 (86.7%) -(IGHD) -IGHJ6*01 (90.9%)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG4*01, G4v5 h P10, G4v22 CH2 T16, P91, CH3 A114 (CH1 (119-216), hinge 1-12 S10>P (226) (217-228), CH2 S16>T (252), V91>P (306) (229-338), CH3 N114>A (432) (339-443), CHS (444-445)) (119-445)], (132-218')-disulfide with kappa light chain (1'-218') [V-KAPPA (Mus musculus IGKV3-2*01 (92.9%) -IGKJ1*01 (100%)/Homo sapiens IGKV3D-11*02 (64.9%) -IGKJ4*01 (90.9%)) CDR-IMGT [10.3.9] (27-36.54-56.93-101) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (224-224'':227-227'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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