Пукситатуг самротекан

Rec. INN (наименование, зарегистрированное ВОЗ)

2760250-80-2

immunoglobulin G1-kappa, anti-[Homo sapiens VTCN1 (V-set domain containing T cell activation inhibitor 1, B7 family member H4, B7H4, B7-H4)], Homo sapiens monoclonal antibody; conjugated to a topoisomerase I inhibitor;
gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV4-34*01 (95.9%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.11] (26-33.51-57.96-106)) (1-117) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 CH1 R120, E12, M14 (CH1 R120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 E12 (356), M14 (358) (341-445), CHS (446-447)) (118-447)], (220-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-17*01 (96.8%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa; 220, 214', 220'', 214''', 226, 226'', 229, 229'' -octakis (thioether) conjugated with N-[31-(3-mercapto-2,5-dioxo-3-pyrrolidinyl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacont-1-yl]-L-valyl-N-[(9S)-9-ethyl-2,3,9,10,13,15-hexahydro-9-hydroxy-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]-L-alaninamide

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