Рагистомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2763222-58-6

immunoglobulin G1-scFv_L-kappa dimer, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1) and anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9, 4-1BB, T cell antigen ILA, CD137)], humanized monoclonal antibody, bispecific;
fused G1-scFv lambda-heavy heavy chain humanized (1-715) [gamma1 anti-CD274 humanized (1-449) [VH (Homo sapiens IGHV3-48*02 (87.8%) -(IGHD) -IGHJ4*01 (85.7%) L123>T (114), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, G1v29 CH2 A84.4 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2 N84.4>A (299) (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)] -15-mer tris(tetraglycyl-seryl) linker (450-464) -scFv lambda-heavy anti-TNFRSF9 humanized scFv-v2 C120 (VL)-C49 (VH) (465-715) [V-LAMBDA (Homo sapiens IGLV1-47*02 (91.8%) -IGLJ2*01 (91.8%) C120 (567), CDR-IMGT [8.3.11] (490-497.515-517.554-564)) (465-574) -20-mer tetrakis(tetraglycyl-seryl) linker (575-594) -VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (620-627.645-652.691-704)) (595-715)]]; (222-214')-disulfide with kappa light chain anti-CD274 humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 (83.2%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153'), V101 (191') (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated

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