Ралудотатуг дерукстекан

Rec. INN (наименование, зарегистрированное ВОЗ)

2610074-57-0

immunoglobulin G1-kappa, anti-[Homo sapiens CDH6 (cadherin 6, K-cadherin (fetal kidney), cadherin 6 type 2)], humanized monoclonal antibody conjugated to deruxtecan, comprising a linker and a camptothecin derivative;
gamma1 heavy chain humanized (1-452) [VH (Homo sapiens IGHV1-3*01 (86.7%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*03, G1m3, nG1m1 (CH1 R120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 E12 (361), M14 (363) (346-450), CHS (451-452)) (123-452)], (225-213')-disulfide with kappa light chain humanized (1'-213') [V-KAPPA (Homo sapiens IGKV1-39*01 (86%) -IGKJ1*01 (91.7%), CDR-IMGT [6.3.8] (27-32.50-52.89-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (152), V101 (190) (107'-213')]; dimer (231-231'': 234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; conjugated, on an average of 8 cysteinyl, to deruxtecan, comprising a linker and a camptothecin derivative

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