Рекатицимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2361290-85-7

immunoglobulin G1-kappa, anti-[Homo sapiens PCSK9 (proprotein convertase subtilisin/kexin type 9, neural apoptosis-regulated convertase 1, NARC1, NARC-1, proproteine convertase 9, PC9)], monoclonal antibody;
gamma1 heavy chain (1-451) [VH (Homo sapiens IGHV1-2*02 (89.8%) -(IGHD) -IGHJ6*01 (100%)) CDR-IMGT [8.8.14] (26-33.51-58.97-110) (1-121) -Homo sapiens IGHG1*01, G1m17,1, G1v21 CH2 Y15.1, T16, E18 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 M15.1>Y (256), S16>T (258), T18>E (260) (235-344), CH3 D12 (360), L14 (362) (345-449), CHS (450-451)) (122-451)], (224-219')-disulfide with kappa light chain (1’-219’) [V-KAPPA (Mus musculus IGKV8-21*01 (85%) -IGKJ4*01 (91.7%)/Homo sapiens IGKV4-1*01 (76.8%) -IGKJ2*02 (100%)) CDR-IMGT [12.3.8] (27-38.56-58.95-102) (1'-112') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (158), V101 (196) (113-219')]; dimer (230-230":233-233")-bisdisulfide, produced in a Chinese Hamster Ovary (CHO) cell line (CHOK1SV GS-KO), glycoform alfa

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