Ремемулген арелактибак

Prop. INN (наименование, предложенное ВОЗ)

non-pathogenic, food-grade lactic acid bacterium Lactococcus cremoris (L. cremoris) strain AUC1000, alr deletion derivative of L. cremoris MG1363, transformed with a plasmid encoding the transgenes for (i) human colony stimulating factor 1 (CSF-1 isoform 3), (ii) human fibroblast growth factor 2 (FGF-2 isoform 3), and (iii) human interleukin 4 (IL-4 isoform-1) whose expression is controlled by a gad operon cassette comprising the gadR regulator gene and a gadCB regulatory region. Each of the three transgenes is optimised for expression in L. cremoris and is coupled to the L. cremoris Usp45 signal sequence preceded by a ribosome binding site derived from the gadC (CSF-1), atpG (FGF-2) and lacA (IL-4) genes of L. cremoris, respectively. The plasmid also contains an alanine racemase (alr) gene for plasmid selection

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