Реозалимаб
ReozalimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2445259-99-2
Химическое название
immunoglobulin G1-kappa_G1-lambda2, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)] and anti-[Homo sapiens CD274 (programmed death ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1)], Homo sapiens monoclonal antibody, bispecific;
gamma1 heavy chain anti-PDCD1 Homo sapiens (1-450) [VH (Homo sapiens IGHV1-69*15 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*08p, G1m3,1, G1v44 CH1 E7, T26, E84.2, G1v14 CH2 A1.3, A1.2, G1v46 CH3 V6, L22, L79, W81 (CH1 L7>E (131), K26>T (150), Q84.2>E (178), I103 (202), R120 (217) (121-218), hinge 1-15 (219-233), CH2 L1.3>A (237), L1.2>A (238), D27>S (268) (234-343), CH3 T6>V (353), D12 (359), L14 (361), T22>L (369), K79>L (395), T81>W (397) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with kappa light chain anti-PDCD1 Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01, Km3 S20>R (131), V22>G (133), A45.1 (153), S86>R (176), V101 (191) (108'-214')];
gamma1 heavy chain anti-CD274 Homo sapiens (1''-453'') [VH (Homo sapiens IGHV1-69*06 (100%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1''-123'') -Homo sapiens IGHG1*08p, G1m3,1, G1v45 CH1 K86, G1v14 CH2 A1.3, A1.2, G1v47 CH3 V6, Y7, A85.1, V86 (CH1 S86>K (189), I103 (205), R120 (220) (124''-221''), hinge 1-15 (222''-236''), CH2 L1.3>A (240), L1.2>A (241), D27>S (271) (237''-346''), CH3 T6>V (356), L7>Y (357), D12 (362), L14 (364), F85.1>A (411), Y86>V (413) (347''-451''), CHS (452''-453'')) (124''-453'')], (226''-215''')-disulfide with lambda2 light chain anti-CD274 Homo sapiens (1'''-216''') [V-LAMBDA (Homo sapiens IGLV1-44*01 (91.8%) -IGLJ2*01 (90.9%) T122>I (105), CDR-IMGT [8.3.11] (26-33.51-53.90-100)) (1'''-110''') -Homo sapiens IGLC2*01, S86>E (179), Y88>E (181), T124>A (213) (111'''-216''')]; dimer (229-232'':232-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
gamma1 heavy chain anti-PDCD1 Homo sapiens (1-450) [VH (Homo sapiens IGHV1-69*15 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*08p, G1m3,1, G1v44 CH1 E7, T26, E84.2, G1v14 CH2 A1.3, A1.2, G1v46 CH3 V6, L22, L79, W81 (CH1 L7>E (131), K26>T (150), Q84.2>E (178), I103 (202), R120 (217) (121-218), hinge 1-15 (219-233), CH2 L1.3>A (237), L1.2>A (238), D27>S (268) (234-343), CH3 T6>V (353), D12 (359), L14 (361), T22>L (369), K79>L (395), T81>W (397) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with kappa light chain anti-PDCD1 Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01, Km3 S20>R (131), V22>G (133), A45.1 (153), S86>R (176), V101 (191) (108'-214')];
gamma1 heavy chain anti-CD274 Homo sapiens (1''-453'') [VH (Homo sapiens IGHV1-69*06 (100%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1''-123'') -Homo sapiens IGHG1*08p, G1m3,1, G1v45 CH1 K86, G1v14 CH2 A1.3, A1.2, G1v47 CH3 V6, Y7, A85.1, V86 (CH1 S86>K (189), I103 (205), R120 (220) (124''-221''), hinge 1-15 (222''-236''), CH2 L1.3>A (240), L1.2>A (241), D27>S (271) (237''-346''), CH3 T6>V (356), L7>Y (357), D12 (362), L14 (364), F85.1>A (411), Y86>V (413) (347''-451''), CHS (452''-453'')) (124''-453'')], (226''-215''')-disulfide with lambda2 light chain anti-CD274 Homo sapiens (1'''-216''') [V-LAMBDA (Homo sapiens IGLV1-44*01 (91.8%) -IGLJ2*01 (90.9%) T122>I (105), CDR-IMGT [8.3.11] (26-33.51-53.90-100)) (1'''-110''') -Homo sapiens IGLC2*01, S86>E (179), Y88>E (181), T124>A (213) (111'''-216''')]; dimer (229-232'':232-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
Структура
Иностранные названия
- Reozalimabum (латинское)
- Reozalimab (английское)
- Reozalimab (немецкое)
- Réozalimab (французское)
- Reozalimab (испанское)
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