Ретлирафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2395839-91-3

human immunoglobulin G4-kappa anti-(human programmed cell death 1 ligand 1, PD-L1) variant (H⁵²>G, G⁵⁷>F, S²²⁷>P, F²³³>A, L²³⁴>A, K⁴⁴⁶>A in the heavy chain and N85>E in the light chain), fused at the C-terminus of both heavy chains (1-446) via peptidyl linker ⁴⁴⁷GGGGSGGGGSGGGGSGGGGSG⁴⁶⁷ to human transforming growth factor β type II (TGFR-2) extracellular fragment (20-136, 468-584 in the current sequence), dimer; glycosylated; produced in Chinese hamster ovary (CHO) cells;
immunoglobulin G4-kappa, anti-[Homo sapiens programmed cell death 1 ligand 1 (PD-L1, programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, B7-H1, CD274)], Homo sapiens monoclonal antibody, fused at the C-terminus of both heavy chains via a (G₄S)₄G peptide linker (447-467) to fragment 20-136 of the extracellular domain of transforming growth factor β receptor type II (Homo sapiens TGF-β receptor 2, TGFR-2, TGFBR2) (468- 584);
gamma4 heavy chain Homo sapiens (1-446) [Homo sapiens IGHV1-46*01; Homo sapiens IGHJ4*01; Homo sapiens IGHG4*01; VH: 1-119 (H52G G57F); CH1: 120-217; hinge 218-229 (S227P); CH2: 230-339 (F233A L234A); CH3: 340-444; CHS: 445-446 (K446A); CDRKabatH1: SYWMH (31-35); CDRKabatH2: RIGPNSGFTSYNEKFKN (50-66); CDRKabatH3: GGSSYDYFDY (99-108)], (133-218')- disulfide with kappa light chain Homo sapiens (1'-218') [Homo sapiens IGKV4-1*01; Homo sapiens IGKJ2*01; Homo sapiens IGKC*01; VL: 1-111 (N85E); CL: 112- 218; CDRKabatL1: RASESVSIHGTHLMH (24-38); CDRKabatL2: AASNLES (54-60); CDRKabatL: QQSFEDPLT (93-101)]; dimer (225-225'':228-228'')- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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