Резетамиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2795115-07-8

immunoglobulin half G4-kappa_G4(VH-h-CH2-CH3), anti-[Homo sapiens CD3E (CD3 epsilon)] and anti-|Homo sapiens CD22 (sialic acid binding Ig-like lectin 2, SIGLEC2, SIGLEC-2, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14)], Homo sapiens monoclonal antibody, bispecific, bivalent;
gamma4 heavy chain anti-CD3E Homo sapiens (1-450) [VH (Homo sapiens IGHV3-9*01 (98.0%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v4 CH2 A1.3, A1.2, G4v32 CH3 W22 (knob) (CH1 (124-221), hinge 1-12 S10>P (231) (222-233), CH2 F1.3>A (237), L1.2>A (238), L92 (312) (234-343), CH3 T22>W (369) (344-448), CHS (449-450)) (124-450)], (137-214')-disulfide with kappa light chain anti-CD3E Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-15*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')];
gamma4 heavy chain anti-CD22 Homo sapiens VH-h-CH2-CH3 (1''-347'') [VH (Homo sapiens IGHV4-39*01 (91.9%) -(IGHD) -IGHJ1*01 W118>R (108'') (85.7%), CDR-IMGT [10.7.10] (26''-35''.53''-59''.98''-107'')) (1''-118'') -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v4 CH2 A1.3, A1.2, G4v33 CH3 S22, A24, V86 (hole) (hinge 1-12 S10>P (128'') (119''-130''), CH2 F1.3>A (134''), L1.2>A (135''), L92 (209'') (131''-240''), CH3 T22>S (266''), L24>A (268''), Y86>V (307'') (241''-345''), CHS (346’’-347'')) (119''-347'')]; dimer (229-126'':232-129'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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