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Prop. INN (наименование, предложенное ВОЗ)

2894138-72-6

immunoglobulin G1-kappa, anti-[Homo sapiens GDF15 (growth differentiation factor 15, macrophage inhibitory cytokine-1, MIC-1, MIC1, non-steroidal anti-inflammatory drug (NSAID)-activated gene-1, NAG-1, NSAID-regulated gene 1, NRG-1, prostate differentiation factor, PDF, placental TGF beta, PTGFB)], humanized monoclonal antibody;
H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV1-69*02 (83.7%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (83.2%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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