Ринатабарт сесутекан

Rec. INN (наименование, зарегистрированное ВОЗ)

2853518-95-1

immunoglobulin G1-kappa, anti-[Homo sapiens FOLR1 (folate receptor 1, folate receptor alpha, FR-alpha, adult folate-binding protein, FBP, ovarian tumor-associated antigen MOv18)], Homo sapiens monoclonal antibody, conjugated on an average of 8 cysteinyl residues to sesutecan, comprising a linker and a camptothecin derivative (exatecan);
H-gamma1 heavy chain Homo sapiens (1-453) [VH (Homo sapiens IGHV3-30*03 (96.9%) -(IGHD) -IGHJ4*01 (92.9%) L123>Q (118), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v14 CH2 A1.3, A1.2 (CH1 K120 (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>A (240), L1.2>A (241) (237-346), CH3 D12 (362), L14 (364) (347-451), CHS (452-453)) (124-453)], (226-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 (93.7%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')]; dimer (232-232'':235-235'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa; substituted at the sulfur atoms of an average of 8 l-cysteinyl residues among 226, 232, 235, 214', 226'', 232'', 235'' and 214''' with radical group 1-[(2R,3R,4R,5S,52S)-1,2,3,4,5-pentahydroxy-52-{[(2S)-1-{[(2S)-5-carbamoylamino-1-oxo-1-{3-[({[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]carbamoyl}oxy)methyl]anilino}pentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamoyl}-7-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-46,54-dioxo-10,13,16,19,22,25,28,31,34,37,40,43-dodecaoxa-7,47,53-triazanonapentacontan-59-yl]-2,5-dioxopyrrolidin-3-yl (sesutecan)

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