Ролинсатамаб талирин

Rec. INN (наименование, зарегистрированное ВОЗ)

2095467-44-8

immunoglobulin G1-kappa, anti-[Homo sapiens PRLR (prolactin receptor)], monoclonal antibody, conjugated to the pyrrolobenzodiazepine (PDB) dimer SGD-1882; gamma1 heavy chain (1-450) [VH (Mus musculus IGHV1-69*02 (82.7%)/Homo sapiens IGHV1-46*01 (79.6%) -(IGHD)-Homo sapiens IGHJ6*01 (90.9%)) [8.8.13] (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 (CH1 R120>K (217) (121-218), hinge (219- 233), CH2 S3>C (242) (234-343), CH3 E12 (359), M14 (361) (344- 448), CHS (449-450)) (121-450)], (223-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Mus musculus IGKV6-13*01 (82.10%)/Homo sapiens IGKV1-12*01 (81.1%) -Homo sapiens IGKJ4*01 (100%)) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229":232-232")- bisdisulfide; conjugated, on two site-specific drug attachment engineered cysteines (C242, C242''), to a maximum of two pyrrolobenzodiazepine (PDB) dimers SGD-1882, each via a cleavable (valine-alanine dipeptide as cathepsine B cleavage site) maleimidocaproyl type linker

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