Ромилкимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB16318

1399584-78-1

immunoglobulin G4-kappa, anti-[Homo sapiens IL13 (interleukin 13, IL-13)] and anti-[Homo sapiens IL4 (interleukin 4, IL-4)], chimeric and humanized monoclonal antibody, bispecific, tetravalent;
gamma1 heavy chain (1-577) [VH anti-IL13 (Mus musculus IGHV2-6-7*01 (83.50%) -(IGHD) -IGHJ4*01 (93.8%)/Homo sapiens IGHV2-26*01 (59.6%) -(IGHD) -IGHJ1*01 (90.9%)) [8.7.12] (1-118) -10-mer linker bis(tetraglycyl-seryl) (119-128) -VH anti-IL4 (Mus musculus IGHV1S127*01 (81.6%) -(IGHD) -IGHJ1*01 (87.5%)/Homo sapiens IGHV1-46*01 (68.4%) -(IGHD) -IGHJ4*01 (86.7%)) [8.8.16] (129-251) -Homo sapiens IGHG4*01 (CH1 (252-349), hinge 1-12, S10>P (359) (350-361), CH2 L1.2>E (366) (362-471), CH3 (472-576), CHS K>del (577)) (252-577)]; (265-335')-disulfide with kappa light chain (1’-335’) [V-KAPPA anti-IL13 (Mus musculus IGKV3-10*01 (92.90%) -IGKJ1*01 (100%)/Homo sapiens) IGKV4-1*01 (71.9%) -IGKJ4*01 (90.9%)) [10.3.9] (1'-111') -10-mer linker bis(tetraglycyl-seryl) (112’-121’) -humanized V-KAPPA anti-IL4 (Homo sapiens IGKV1-12*01 (76.8%) -IGKJ2*02 (90.9%)) [6.3.9] (122’-228’) -Homo sapiens IGKC*01, Km3 A45.1 (274), V101 (312) (229'-335')]; dimer (357-357":360-360")-bisdisulfide

Поделиться этой страницей