Роснилимаб
RosnilimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
USAN (наименование, принятое к употреблению в США)
PubChem
445594987
CAS
2412764-40-8
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV7-4-1*02 (87.8%) -(IGHD) -IGHJ4*01 (92.3%) L123>T (116), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 (235-344), CH3 D12 (360), L14 (362) (345-449), CHS (450-451)) (122-451)], (224-215')-disulfide with kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV3D-11*02 (86.8%) -IGKJ4*01 (100%), CDR-IMGT [7.3.9] (27-33.51-53.90-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV7-4-1*02 (87.8%) -(IGHD) -IGHJ4*01 (92.3%) L123>T (116), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01 (100%), G1m17,1 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 (235-344), CH3 D12 (360), L14 (362) (345-449), CHS (450-451)) (122-451)], (224-215')-disulfide with kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV3D-11*02 (86.8%) -IGKJ4*01 (100%), CDR-IMGT [7.3.9] (27-33.51-53.90-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
Структура
Иностранные названия
- Rosnilimabum (латинское)
- Rosnilimab (английское)
- Rosnilimab (немецкое)
- Rosnilimab (французское)
- Rosnilimab (испанское)
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