Ровалпитузумаб тесирин
Rovalpituzumab tesirineМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
USAN (наименование, принятое к употреблению в США)
Drugbank
DB13017
CAS
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens DLL3 (delta-like ligand 3)], humanized monoclonal antibody conjugated to the pyrrolobenzodiazepine (PBD) dimer SCX;
gamma1 heavy chain (1-447) [humanized VH (Homo sapiens IGHV1-18*01 (86.700%) -(IGHD)-IGHJ4*01) [8.8.11] (1-118) -Homo sapiens IGHG1*01 G1m17,1 (CH1 (119-216), hinge (217-231), CH2 (232-341), CH3 (342- 446), CHS K2>del (447)) (119-447)], (221-214')-disulfide with kappa light chain (1’-214’) [humanized V-KAPPA (Homo sapiens IGKV3-15*01 (87.40%) -IGKJ2*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (227-227":230-230")-bisdisulfide; conjugated, on an average of 2 cysteines, to the pyrrolobenzodiazepine (PBD) dimer SCX, via a cleavable (valine-alanine dipeptide as cathepsine B cleavage site) maleimide type linker containing a spacer PEG (n=8)
gamma1 heavy chain (1-447) [humanized VH (Homo sapiens IGHV1-18*01 (86.700%) -(IGHD)-IGHJ4*01) [8.8.11] (1-118) -Homo sapiens IGHG1*01 G1m17,1 (CH1 (119-216), hinge (217-231), CH2 (232-341), CH3 (342- 446), CHS K2>del (447)) (119-447)], (221-214')-disulfide with kappa light chain (1’-214’) [humanized V-KAPPA (Homo sapiens IGKV3-15*01 (87.40%) -IGKJ2*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (227-227":230-230")-bisdisulfide; conjugated, on an average of 2 cysteines, to the pyrrolobenzodiazepine (PBD) dimer SCX, via a cleavable (valine-alanine dipeptide as cathepsine B cleavage site) maleimide type linker containing a spacer PEG (n=8)
Структура
Иностранные названия
- Rovalpituzumabum tesirinum (латинское)
- Rovalpituzumab tesirine (английское)
- Rovalpituzumab tesirin (немецкое)
- Rovalpituzumab tésirine (французское)
- Rovalpituzumab tesirina (испанское)
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