Розибафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2143449-47-0

immunoglobulin G2-kappa, anti-[human inducible costimulator (ICOS) ligand protein] human monoclonal antibody, fused with two copies of a tumor necrosis factor ligand superfamily member 13B (TNFSF13B, B-cell activating factor, BAFF)-binding peptide, glycoform alfa:
gamma2 heavy chain [Homo sapiens VH (Homo sapiens IGHV3-7*01 - (IGHD)-IGHJ1*01) [CDRKabatH1: SYWMS (31-35); CDRKabatH2: YIKQDGNEKYYVDSVKG (50-66); CDRKabatH3: EGILWFGDLPTF (99-110)] (1-121) - Homo sapiens IGHG2*01 (CH1 (122-219), hinge (220-231), CH2 (232-340), CH3 (341-445), CHS (446-447))] (1-447) fused by a G₅ linker (448-452) and a (GS)₂ATG(GS)₂VASS(GS)₂ATHL linker (471-493) with two copies of a synthetic human tumor necrosis factor ligand superfamily member 13B (TNFSF13B, B cell-activating factor, BAFF)-binding peptide (453-470, 494-511), (135-214')-disulfide with kappa light chain [V-KAPPA (Homo sapiens IGKV1D-16*01 - IGKJ1*01) [CDRKabatL1: RASQGISNWLA (24-34); CDRKabatL2: AASSLQS (50-56); CDRKabatL3: QQYDSYPRT (89-97)] (1'-107') - Homo sapiens IGKC*01 (108'-214')] (1'-214'), (223-223'',224-224'',227- 227'',230-230'')-tetrakisdisulfide dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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