Рулонилимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2417124-95-7

immunoglobulin G1-kappa, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)], monoclonal antibody;
gamma1 heavy chain (1-448) [VH Musmus/Homsap (Mus musculus IGHV5-9-2*01 (95.9%) -(IGHD) -IGHJ4*01 (83.3%) S123>L (113)/Homo sapiens IGHV3-23*04 (82.7%) -(IGHD) -IGHJ3*01 (90.9%) M123>L (113), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, G1v29 CH2 A84.4, G1v42 CH2 Q14, CH3 L107 (CH1 R120>K (215) (119-216), hinge 1-15 (217-231), CH2 T14>Q (251), N84.4>A (298) (232-341), CH3 E12 (357), M14 (359), M107>L (429) (342-446), CHS (447-448)) (119-448)], (221-218')-disulfide with kappa light chain (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-2*01 (92.9%) -IGKJ1*01 (100%)/Homo sapiens IGKV3D-11*02 (67.7%) -IGKJ4*01 (90.9%) V124>L (108), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO)/dhFr- cell line lacking the enzyme dihydrofolate reductase (DHFR), non-glycosylated

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