Рузалтатуг резетекан

Rec. INN (Recommended International Nonproprietary Name) — рекомендованное международное непатентованное наименование

2981438-67-7

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB3 (receptor tyrosin-protein kinase erbB-3, HER3)], Homo sapiens monoclonal antibody, conjugated on an average of four cysteinyl residues to rezetecan, comprising a linker and a camptothecin derivative (exatecan);
H-gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV3-9*01 (97.0%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 D12 (356), L14 (358) (341-445), CHS (446-447)) (118-447)], (220-215')-disulfide with L-kappa light chain Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV1-39*01 (87.4%) -IGKJ2*04 (90.9%) L124>V (105'), CDR-IMGT [6.3.10] (27'-32'.50'-52'.89'-98')) (1'-108') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (154'), V101 (192')) (109'-215')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa; substituted at the sulfur atoms of four l-cysteinyl residues on an average among 215', 215''', 220, 220'', 226, 226'', 229 and 229'' with (3RS)-1-[(2R,10S)-10-benzyl-2-cyclopropyl-1-{[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino}-1,6,9,12,15,18-hexaoxo-3-oxa-5,8,11,14,17-pentaazatricosan-23-yl]-2,5-dioxopyrrolidin-3-yl (rezetecan) groups

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