Сафиместомиг
SafimestomigМНН
Prop. INN (наименование, предложенное ВОЗ)
CAS
2911590-72-0
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3)] and anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)], humanized monoclonal antibody, bispecific, bivalent;
H-gamma4 heavy chain anti-CD47 humanized (1-451) [VH (Homo sapiens IGHV1-3*01 (85.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG4*01 nG4m(a) CH2 L92, G4v5 h P10, G4v6 CH3 K88, G4v11 CH1 Q100, CH2 Y84.3, G4v12 CH3 K12, R115 (CH1 K100>Q (203) (125-222), hinge 1-12 S10>P (232) (223-234), CH2 F84.3>Y (300), L92 (313) (235-344), CH3 E12>K (360), R88>K (413), H115>R (439) (345-449), CHS (450-451)) (125-451)], (138-214')-disulfide with common L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (88.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')];
H-gamma4 heavy chain anti-PD-L1 humanized (1''-446'') [VH (Homo sapiens IGHV1-69-2*01 (82.7%) -(IGHD) -IGHJ4*01 (92.9%) L123>T (114), CDR-IMGT [8.8.12] (26''-33''.51''-58''.97''-108'')) (1''-119'') -Homo sapiens IGHG4*01 nG4m(a) CH2 L92, G4v5 h P10, G4v6 CH3 K88, G4v11 CH1 Q100, CH2 Y84.3, G4v13 CH3 E119 (CH1 K100>Q (198'') (120''-217''), hinge 1-12 S10>P (227'') (218''-229''), CH2 F84.3>Y (295''), L92 (308'') (230''-339''), CH3 R88>K (408''), K119>E (438'') (340''-444''), CHS (445’’-446'')) (120''-446'')], (133''-214''')-disulfide with common L-kappa light chain humanized (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (88.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'''-32'''.50'''-52'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'''), V101 (191''')) (108'''-214''')]; dimer (230-225'':233-228'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa
H-gamma4 heavy chain anti-CD47 humanized (1-451) [VH (Homo sapiens IGHV1-3*01 (85.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG4*01 nG4m(a) CH2 L92, G4v5 h P10, G4v6 CH3 K88, G4v11 CH1 Q100, CH2 Y84.3, G4v12 CH3 K12, R115 (CH1 K100>Q (203) (125-222), hinge 1-12 S10>P (232) (223-234), CH2 F84.3>Y (300), L92 (313) (235-344), CH3 E12>K (360), R88>K (413), H115>R (439) (345-449), CHS (450-451)) (125-451)], (138-214')-disulfide with common L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (88.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')];
H-gamma4 heavy chain anti-PD-L1 humanized (1''-446'') [VH (Homo sapiens IGHV1-69-2*01 (82.7%) -(IGHD) -IGHJ4*01 (92.9%) L123>T (114), CDR-IMGT [8.8.12] (26''-33''.51''-58''.97''-108'')) (1''-119'') -Homo sapiens IGHG4*01 nG4m(a) CH2 L92, G4v5 h P10, G4v6 CH3 K88, G4v11 CH1 Q100, CH2 Y84.3, G4v13 CH3 E119 (CH1 K100>Q (198'') (120''-217''), hinge 1-12 S10>P (227'') (218''-229''), CH2 F84.3>Y (295''), L92 (308'') (230''-339''), CH3 R88>K (408''), K119>E (438'') (340''-444''), CHS (445’’-446'')) (120''-446'')], (133''-214''')-disulfide with common L-kappa light chain humanized (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (88.4%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'''-32'''.50'''-52'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'''), V101 (191''')) (108'''-214''')]; dimer (230-225'':233-228'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa
Структура
Иностранные названия
- Safimestomigum (латинское)
- Safimestomig (английское)
- Safimestomig (немецкое)
- Safimestomig (французское)
- Safimestomig (испанское)
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