Самататуг зодотин

Prop. INN (наименование, предложенное ВОЗ)

2861288-58-4

immunoglobulin G1-kappa, anti-[Homo sapiens F3 (coagulation factor III (thromboplastin, tissue factor), CD142)], Homo sapiens monoclonal antibody, conjugated on an average of 4 cysteinyl residues via a cleavable linker to a derivative of auristatin;
H-gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV1-18*01 (94.9%) -(IGHD) -IGHJ3*01 (92.3%) M123>T (118), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (220) (124-221), hinge 1-15 (222-236), CH2 (237-346), CH3 E12 (362), M14 (364) (347-451), CHS K2>del (452)) (124-452)], (226-215')-disulfide with L-kappa light chain Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV1-5*03 (91.4%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.10] (27'-32'.50'-52'.89'-98')) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')]; dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-DG44, co-expressing the enzyme dihydrofolate reductase (DHFR), glycoform alfa; substituted at the sulfur atoms of four l-cysteinyl residues on an average among 226, 232, 235, 215', 226'', 232'', 235'' and 215''' with radical group (3RS)-1-[(6S,9S)-1-amino-6-{[4-({N,N-dimethyl-l-valyl-l-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(2R,3R)-3-methoxy-2-methyl-3-[(2S)-pyrrolidin-2-yl]propanoyl}sulfamoyl)phenyl]carbamoyl}-1,8,11-trioxo-9-(propan-2-yl)-14,17,20-trioxa-2,7,10-triazadocosan-22-yl]-2,5-dioxopyrrolidin-3-yl (zovodotin)

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