Сапецмеран аутоген

Prop. INN (наименование, предложенное ВОЗ)

2805319-17-7

elf-amplifying messenger RNA (samRNA), 5' capped, based on Venezuelan equine encephalitis virus (VEEV) (wildtype Trinidad donkey strain) genomic RNA in which the coding sequences for the VEEV structural proteins have been deleted and replaced by a patient-specific cassette expressing 20 tumour-specific neoantigens (TSNAs). The expression cassette comprises coding sequences for methionine, alanine and glycine (MAG), the 20 patient-specific TSNAs, and an MHC class II helper domain consisting of two universal CD4+ T helper lymphocyte epitopes, PADRE (pan HLA DR-binding epitope) and tetanus toxoid P2 (amino acids 830-844 of tetanus toxin Tc), linked by glycine-proline linkers (GPGPG)., The expression cassette is under the control of the VEEV subgenomic 26S promoter located 5' of the inserted TSNA cassette. The samRNA also encodes codon-optimized VEEV non-structural proteins 1-4 (nsP1-4) plus the 5' and 3' RNA sequences required for RNA replication

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