Симридарлимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2378862-90-7

immunoglobulin (G1_L-kappa)_VH-VH-h-CH2-CH3, anti-[Homo sapiens CD47 (leukocyte surface antigen CD47, integrin associated protein, IAP, MER6, OA3] and anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, B7H1, B7-H1, PDL1, PD-L1, PDCD1L1, B7 homolog 1)], Homo sapiens and humanized monoclonal antibody, bispecific;
gamma1 heavy chain Homo sapiens anti-CD47 (1-444) [VH anti-CD47 (Homo sapiens IGHV4-59*01 (97.9%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.9] (26-33.51-57.96-104)) (1-115) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2, G1v32 CH3 W22 (CH1 K120 (212) (116-213), hinge 1-15 (214-228), CH2 L1.3>A (232), L1.2>A (233) (229-338), CH3 S10>C (352), D12 (354), L14 (356), T22>W (364) (339-443), CHS K2>del (444)) (116-444)], (218-214')-disulfide with kappa light chain Homo sapiens anti-CD47 (1'-214') [V-KAPPA anti-CD47 (Homo sapiens IGKV1-12*01 (96.8%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')];
gamma1 VH-VH-h-CH2-CH3 chain humanized anti-CD274 (1''-510'') [VH anti-CD274 (Homo sapiens IGHV3-66*01 (81.2%) -(IGHD) -IGHJ5*02 (100%), CDR-IMGT [8.7.26] (26-33.51-57.96-121)) (1''-132'')] -20 mer tetrakis(tetraglycyl-seryl) linker (133''-152'') -[VH anti-CD274 (Homo sapiens IGHV3-66*01 (81.2%) -(IGHD) -IGHJ5*02 (100%), CDR-IMGT [8.7.26] (178-185.203-209.248-273)) (153''-284'') -Homo sapiens IGHG1*01 h-CH2-CH3, G1m17, G1v14 CH2 A1.3, A1.2, G1v33 S22, A24, V86 (hinge 1-10 (285''-294''), CH2 L1.3>A (298), L1.2>A (299) (295''-404''), CH3 Y5>C (413), D12 (420), L14 (422), T22>S (430), L24>A (432), Y86>V (471) (405''-509''), CHS K2>del (510'')) (285''-510'')], dimer (224-290'':227-293'':352-413'')-trisdisulfide, produced in Chinese hamster ovary (CHO)-K1SV cell line lacking the glutamine synthetase gene (GS-KO), glycoform alfa

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