Сирексатамаб
SirexatamabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2414962-49-3
Химическое название
immunoglobulin G4-kappa, anti-[Homo sapiens DKK1 (dickkopf WNT signaling pathway inhibitor 1, SK, DKK-1)], humanized monoclonal antibody;
gamma4 heavy chain humanized (1-445) [VH (Homo sapiens IGHV3-7*01 (90.8%) -(IGHD) -IGHJ3*02 (92.9%) M123>T (114), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG4*01, G4v5 h P10, G4v4 CH2 A1.3, A1.2 (CH1 (120-217), hinge 1-12 S10>P (227) (218-229), CH2 F1.3>A (233), L1.2>A (234) (230-339), CH3 (340-444), CHS K2>del (445)) (120-445)], (133-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3-11*01 (84.2%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (225-225'':228-228'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-derived cell line, glycoform alfa
gamma4 heavy chain humanized (1-445) [VH (Homo sapiens IGHV3-7*01 (90.8%) -(IGHD) -IGHJ3*02 (92.9%) M123>T (114), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG4*01, G4v5 h P10, G4v4 CH2 A1.3, A1.2 (CH1 (120-217), hinge 1-12 S10>P (227) (218-229), CH2 F1.3>A (233), L1.2>A (234) (230-339), CH3 (340-444), CHS K2>del (445)) (120-445)], (133-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3-11*01 (84.2%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (225-225'':228-228'')-bisdisulfide, produced in a Chinese hamster ovary (CHO)-derived cell line, glycoform alfa
Структура
Иностранные названия
- Sirexatamabum (латинское)
- Sirexatamab (английское)
- Sirexatamab (немецкое)
- Sirexatamab (французское)
- Sirexatamab (испанское)
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