Софитузумаб ведотин
Sofituzumab vedotinМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB15349
CAS
1418200-58-4
Химическое название
immunoglobulin G1-kappa auristatin E conjugate, anti-[Homo sapiens MUC16 (mucin 16, MUC-16, cancer antigen 125, CA125)], humanized monoclonal antibody conjugated to auristatin E;
gamma1 heavy chain (1-446) [humanized VH (Homo sapiens IGHV3-48*03 (79.80%) -(IGHD)-IGHJ4*01) [9.8.9] (1-116) -Homo sapiens IGHG1*03 (CH1 R120>K (213) (117-214), hinge (215-229), CH2 (230-339), CH3 (340-444), CHS (445-446)) (117-446)], (219- 214')-disulfide with kappa light chain (1'-214') [humanized V-KAPPA (Homo sapiens IGKV1-5*01 (87.90%) -IGKJ1*01) [6.3.9] (1'-107') - Homo sapiens IGKC*01 (108'-214')]; dimer (225-225":228-228")- bisdisulfide; conjugated, on an average of 3 to 4 cysteinyl, to monomethylauristatin E (MMAE), via a cleavable maleimidocaproylvalyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker
gamma1 heavy chain (1-446) [humanized VH (Homo sapiens IGHV3-48*03 (79.80%) -(IGHD)-IGHJ4*01) [9.8.9] (1-116) -Homo sapiens IGHG1*03 (CH1 R120>K (213) (117-214), hinge (215-229), CH2 (230-339), CH3 (340-444), CHS (445-446)) (117-446)], (219- 214')-disulfide with kappa light chain (1'-214') [humanized V-KAPPA (Homo sapiens IGKV1-5*01 (87.90%) -IGKJ1*01) [6.3.9] (1'-107') - Homo sapiens IGKC*01 (108'-214')]; dimer (225-225":228-228")- bisdisulfide; conjugated, on an average of 3 to 4 cysteinyl, to monomethylauristatin E (MMAE), via a cleavable maleimidocaproylvalyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker
Молярная масса
144,7 кг/моль
Структура
Иностранные названия
- Sofituzumabum vedotinum (латинское)
- Sofituzumab vedotin (английское)
- Sofituzumab vedotin (немецкое)
- Sofituzumab védotine (французское)
- Sofituzumab vedotina (испанское)
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