Солабафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2918752-58-4

humanized immunoglobulin G4-kappa, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)] fused at the C- terminus of each heavy chain via a (G4S)3 linker to human lipocalin-2 (neutrophil gelatinase-associated lipocalin, NGAL, oncogene 24p3, siderocalin) engineered (23 exchanged residues) to bind CD137 (tumor necrosis factor receptor superfamily member 9, TNFRSF9, 4-1BB); gamma 4 heavy chain (1-446) [VH (Homo sapiens IGHV4- 4*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.16.12] (31-35.50- 65.98-109)) (1-120) -Homo sapiens IGHG4*01 (CH1 (121- 218), hinge S²²⁸>P (219-230), CH2 F²³⁴>A, L²³⁵>A (231-340), CH3 (341-445), CHS K⁴⁴⁷>del (446)) (122-447)] fused via peptide linker ⁴⁴⁷GGGGSGGGGSGGGGS⁴⁶¹ to human lipocalin-2 [mutant Q²⁸>H⁴⁸⁹, L³⁶>Q⁴⁹⁷, ⁴⁰AI⁴¹>⁵⁰¹IR⁵⁰², ⁴⁹Q>I⁵¹⁰, Y⁵²>M⁵¹³, N⁶⁵>D⁵²⁶, S⁶⁸>M⁵²⁹, L⁷⁰>K⁵³¹, ⁷²RK⁷³>⁵³³DD⁵³⁴, D⁷⁷>M⁵³⁸, W⁷⁹>D⁵⁴⁰, R⁸¹>W⁵⁴², C⁸⁷>S⁵⁴⁸, N⁹⁶>K⁵⁵⁷, Y¹⁰⁰>F⁵⁶¹, L¹⁰³>H⁵⁶⁴, Y¹⁰⁶>S⁵⁶⁷, K¹²⁵>F⁵⁸⁶, S¹²⁷>F⁵⁸⁸, Y¹³²>E⁵⁹³, K¹³⁴>Y⁵⁹⁵ (1-178)] (462-639 in the current sequence), (134-214')- disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV6-21*02 -IGKJ2*01, CDR-Kabat [11.7.9] (24'- 34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'- 214')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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