Солизместроцел

Rec. INN (наименование, зарегистрированное ВОЗ)

allogeneic mesenchymal stromal cells (MSC) derived from genetically selected umbilical cord tissue. The cord tissue is enzymatically digested, and the cells cultured in a xeno-free medium supplemented with human platelet lysate. The cells are positive (>90%) for the mesenchymal stromal cell surface markers CD105+, CD73+, CD90+, and are negative (<10%) for CD45-, CD34-, CD19-, CD11b-, and HLA-DR-. The cells release anti-fibrotic molecules such as matrix metalloproteinase-1 (MMP-1) and microRNA-29c (miR-29c). The cells also inhibit T lymphocyte proliferation upon CD3/CD28/CD2 activation, suppress tumor necrosis factor alpha (TNFα) secretion of immune cells (peripheral blood mononuclear cells /macrophages) upon lipopolysaccharides (LPS) stimulation, and upregulate soluble TNF receptor 1 and 2 secretion upon TNFα/interferon gamma (IFN-γ) stimulation

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