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Prop. INN (наименование, предложенное ВОЗ)

feline allogeneic mesenchymal stem cells (MSCs) isolated from the abdominal cavity of donor cats. The allogeneic mesenchymal stem cells are isolated from excised minced uterine tissue by enzymatic digestion, washed and then cryopreserved as a master cell bank. The MSCs are expanded in media containing heparin, fetal bovine serum (FBS), human insulin, hydrocortisone, human transferrin, fibroblast growth factor 2 (FGF-2), tumour necrosis factor alpha (TNF-α) and platelet-derived growth factor containing two B subunits (PDGF-BB).
, The cells are negative (<10%) for CD34, CD45, and major histocompatibility complex class II (MHC II) molecules (HLA-DR/HLA-DP/HLA-DQ) and are comprised of both stromal (≥60%) and epithelial (≤40%) precursor cells. The stromal progenitor cell population is CD105 (60-100%) and CD44 positive (90- 100%), while the epithelial progenitor cell population is CD105 negative and a mixture of CD44 positive and negative. The cells secrete anti-inflammatory and immune modulating cytokines (prostaglandin E2 (PGE2) and demonstrate expression of indoleamine 2,3-dioxygenase 1 (IDO-1) and CXC-motif chemokine ligand-9 (CXCL-9)

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