Сотевтамаб
SotevtamabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2411526-47-9
Химическое название
immunoglobulin G2-kappa, anti-[Homo sapiens CLU (clusterin, complement lysis inhibitor, CLI, sulfated glycoprotein 2, SGP-2,SP-40, testosterone-repressed prostate message 2, TRPM-2, apolipoprotein J, APOJ, KUB1)], humanized monoclonal antibody;
gamma2 heavy chain humanized (1-443) [VH (Homo sapiens IGHV1-69-2*01 (85.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG2*01 (100%), G2m.. CH2 V45.1 (CH1 (118-215), hinge 1-12 (216-227), CH2 V45.1 (278) (228-336), CH3 (337-441), CHS (442-443)) (118-443)], (131-219')-disulfide with kappa light chain humanized (1'-219') [V-KAPPA (Homo sapiens IGKV4-1*01 (91.9%) -IGKJ2*02 (100%), CDR-IMGT [12.3.8] (27-38.56-58.95-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (219-219'':220-220'':223-223'':226-226'')-tetrakisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa
gamma2 heavy chain humanized (1-443) [VH (Homo sapiens IGHV1-69-2*01 (85.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG2*01 (100%), G2m.. CH2 V45.1 (CH1 (118-215), hinge 1-12 (216-227), CH2 V45.1 (278) (228-336), CH3 (337-441), CHS (442-443)) (118-443)], (131-219')-disulfide with kappa light chain humanized (1'-219') [V-KAPPA (Homo sapiens IGKV4-1*01 (91.9%) -IGKJ2*02 (100%), CDR-IMGT [12.3.8] (27-38.56-58.95-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (219-219'':220-220'':223-223'':226-226'')-tetrakisdisulfide, produced in a Chinese hamster ovary (CHO) cell line derived from CHO-K1, glycoform alfa
Структура
Иностранные названия
- Sotevtamabum (латинское)
- Sotevtamab (английское)
- Sotevtamab (немецкое)
- Sotévtamab (французское)
- Sotevtamab (испанское)
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