Сотибурафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2637466-37-4

humanized vascular endothelial growth factor receptor 1 (VEGFR-1, Fms-like tyrosine kinase 1, FLT-1) extracellular domain fragment (129- 228, 1-100 in the current sequence) fused via the peptide linker ¹⁰¹GGSGGSGGSGGSGGS¹¹⁵ to the N-terminus of the heavy chain (116-564) of a humanized immunoglobulin G1-kappa anti-(human programmed cell death 1 ligand 1 (PD-L1, CD274) heavy chain variant L³⁵²>A, L³⁵³>A; disulfide bridged dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa;
humanized monoclonal antibody fusion with human VEGF receptor type 1; antigen: human programmed cell death 1 ligand 1, PD-L1, programmed death ligand 1, PDCD1 ligand 1, B7 homolog 1, B7-H1 (CD274); CDR Source: Mus musculus; chain length: 564; fusion protein: 1-100 (domain 2 of the mature human extracellular domain of vascular endothelial growth factor receptor type-1 (VEGFR-1, VEGFR1) VEGF type 1 receptor); linker: 101-115; type: IgG1-kappa; heavy chain class: gamma1; HV germline: Homo sapiens IGHV1-3*01; HJ germline: Homo sapiens IGHJ4*01; HC germline: Homo sapiens IGHG1*03; VH: 116-235; CH1: 236-333; hinge: 334-348; CH2: 349-458 (L352A L353A, reduce FcGammaR and C1q binding); CH3: 459-563; CHS: 564-564 (K565del); CDR Kabat H1: GYTIH (146-150); CDR Kabat H2: WFYPGSGTLKYSEKFQG (165-181); CDR Kabat H3: HGTGTLMAMDY (214-224); light chain class: kappa; light chain length: 219; LV germline: Homo sapiens IGKV2-29*02; LJ germline: Homo sapiens IGKJ2*01; LC germline: Homo sapiens IGKC*01; VL: 1-112; CL: 113-219; CDR Kabat L1: KSSQSLANSYGNTYLS (24-39); CDR Kabat L2: GISNRFS (55-61); CDR Kabat L3: LQGTHQPPT (94-102)

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