Сотигалимаб
SotigalimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB16413
CAS
2305607-45-6
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens CD40 (tumor necrosis factor receptor superfamily member 5, TNFRSF5)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-30*01 (79.8%) -(IGHD) - IGHJ1*01 (90.9%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG1*01 G1m17,1 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 S29>E (270) (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-215')-disulfide with kappa light chain humanized (1’-215’) [V-KAPPA (Homo sapiens IGKV1-27*01 (91%) -IGKJ4*01 (100%)) CDR-IMGT [6.3.13] (27-32.50-52.89-101) (1'-108') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (154), V101 (192) (109'-215')];
dimer (229-229":232-232")-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-derived cell line, glycoform alfa
gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-30*01 (79.8%) -(IGHD) - IGHJ1*01 (90.9%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Homo sapiens IGHG1*01 G1m17,1 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 S29>E (270) (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-215')-disulfide with kappa light chain humanized (1’-215’) [V-KAPPA (Homo sapiens IGKV1-27*01 (91%) -IGKJ4*01 (100%)) CDR-IMGT [6.3.13] (27-32.50-52.89-101) (1'-108') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (154), V101 (192) (109'-215')];
dimer (229-229":232-232")-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-derived cell line, glycoform alfa
Структура
Иностранные названия
- Sotigalimabum (латинское)
- Sotigalimab (английское)
- Sotigalimab (немецкое)
- Sotigalimab (французское)
- Sotigalimab (испанское)
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