Спеватамиг

Prop. INN (наименование, предложенное ВОЗ)

2928515-36-8

immunoglobulin (H-gamma1_L-kappa)_(H-gamma1_L-kappa), anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3) and anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, SFTPJ, surfactant associated protein J) isoform 2], bispecific;
H-gamma1 heavy chain anti-CD47 (1-444), G1v92-1 VH E44, CH1 E77 [VH E44 (Homo sapiens IGHV1-46*01 (87.6%) Q44>E (39') -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.7] (26-33.51-58.97-103)) (1-114) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, CH1 E77, G1v93 CH1 C12, G1v37 h S5, G1v74 CH3 C10, G1v32 CH3 W22 (knob) (CH1 K12>C (130), G77>E (163), K120 (211) (115-212), hinge 1-15 C5>S (217) (213-227), CH2 (228-337), CH3 S10>C (351), D12 (353), L14 (355), T22>W (363) (338-442), CHS (443-444)) (115-444)], (130-209')- disulfide with L-kappa light chain anti-CD47 (1'-214') Kv92-1 V-KAPPA K44, C-KAPPA K3 [V-KAPPA K44 (Homo sapiens IGKV3-20*01 (83.3%) Q44>K (38') -IGKJ1*01 (91.7%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (98.1%) Km3 A45.1, V101, K3, KCv37 C121, S126 (C-KAPPA S3>K (114'), A45.1 (153'), V101 (191'), F121>C (209'), C126>S (214')) (108'-214')];
H-gamma1 heavy chain anti-CLDN18 (1-449), G1v92-2 VH K44, CH1 K77 [VH K44 (Homo sapiens IGHV3-48*01 (87.8%) Q44>K (39'') -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.12] (26''-33''.51''-58''.97''-108'')) (1''-119'') -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, CH1 K77, G1v75 CH3 C5, G1v33 CH3 S22, A24, V86 (hole) (CH1 G77>K (168''), K120 (216'') (120''-217''), hinge 1-15 (218''-232''), CH2 (233''-342''), CH3 Y5>C (351''), D12 (358''), L14 (360''), T22>S (368''), L24>A (370''), Y86>V (409'') (343''-447''), CHS (448''-449'')) (120''-449'')], (222''-220''')-disulfide with L-kappa light chain anti-CLDN18 (1'''-220''') Kv92-2 V-KAPPA E44, C-KAPPA E3 [V-KAPPA E44 (Musmus/Homsap (Mus musculus IGKV8-19*01 (79.2%) Q44>E (44''') -IGKJ2*03 (81.8%) S120>Q (106'''), L124>V (110''')/Homo sapiens IGKV1-39*01 (78.2%) Q44>E (44''') -IGKJ1*01 (100%), CDR -IMGT [12.3.9] (27'''-38'''.56'''-58'''.95'''-103''')) (1'''-113''') -Homo sapiens IGKC*01 (99.1%) Km3 A45.1, V101, E3 (C-KAPPA S3>E (120'''), A45.1 (159'''), V101 (197''')) (114'''-220''')]; dimer (223-228'':226-231'':351-351'')-trisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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