Спунолейцел

Prop. INN (наименование, предложенное ВОЗ)

allogeneic peripheral blood mononuclear cells (PBMCs) isolated by apheresis from donors seropositive for respiratory syncytial virus (RSV), influenza A virus, human metapneumovirus (hMPV) and parainfluenza virus (PIV).
The PBMCs are co-cultured with viral peptide mixes spanning immunogenic antigens from RSV (N, F), influenza A (NP1, MP1), PIV (M, HN, N, F), and hMPV (F, N, M2-1, M) in media containing human AB serum, interleukin 4 (IL-4) and interleukin 7 (IL-7).
The final cell population consists of ≥ 90% CD3+ T lymphocytes (mix of CD4+/CD8+ T lymphocytes). The cells produce interferon gamma (IFN-γ) in response to stimulation with RSV, influenza A, hMPV and PIV specific peptides. Cells are stored according to human leukocyte antigen (HLA) type

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